Learn more about Microfluidic Modulation Spectroscopy

Keep up-to-date on the latest developments in Microfluidic Modulation Spectroscopy (MMS), biophysical characterization and RedShiftBio by regularly visiting us here. On this page you will find our comprehensive resources, highlights from new papers and other interesting materials that will help you characterize proteins.

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Confident Differentiation of <2% changes in Secondary Structure to Compare Batch-to-Batch Activity using Microfluidic Modulation Spectroscopy (MMS)

Dr Patrick King & Dr Mike Williams RedShiftBio & Susana De Jesús Acosta, Dr Roser Llevadot, BioKit

Pressure-Perturbation Of Protein Secondary Structure Coupled With Microfluidic Modulation Spectroscopy

Pressure-perturbation of protein secondary structure coupled with Microfluidic Modulation Spectroscopy – a powerful platform for biopharmaceutical formulations development

Vera Gross, Gary Smejkal, Nicole Cutri, Alexander Lazarev (Pressure Biosciences) Libo Wang, John Linnan, Matthew McGann, Jeffrey Zonderman, (RedShiftBio)


Comparability, Similarity, Linearity and High Order Structure Analysis of an IgG1 Sample by Microfluidic Modulation Spectroscopy

Libo Wang, Lucy Liu, Jason Rouse, Eugene Ma and Jeffery Zonderman RedShift BioAnalytics, Inc, Pfizer, Inc.


Microfluidic Modulation Spectroscopy (MMS) - a novel automated infrared (IR) spectroscopic tool for secondary structure analysis of biopharmaceuticals with high sensitivity and repeatability.

Dipanwita Batabyal, Harrison Lord, and Mats Wikström, Attribute Sciences, Amgen Inc, and Libo Wang, John Linnan and Jeffrey Zonderman,RedshiftBio

Microfluidic Modulation Spectroscopy Analysis

Microfluidic Modulation Spectroscopy Analysis of a Monoclonal Antibody at Different Concentrations.

Libo Wang RedShiftBio, Ioannis A. Papayannopoulos Celldex


Structural Characterization of the Insulin-Degrading Enzyme by Microfluidic Modulation Spectroscopy.

Valerie Ivancic, Clark University & Libo Wang, RedShiftBio

Microfluidic Modulation Spectroscopy For Protein Charaterization A Case Study With EcoCRM, CRM197 Carrier Protein

Microfluidic Modulation Spectroscopy for protein Charaterization A Case Study with EcoCRM, CRM197 Carrier Protein

Andrew Lees, Min-Ju Chang and Libo Wang


Microfluidic Modulation Spectroscopy of a Biotherapeutic at Low to High Concentrations without Interference from Formulation Excipients.

Libo Wang and Jeffrey Zonderman, RedShiftBio, and Ioannis A. Papayannopoulos and Shannon Renn-Bingham, Celldex


HOS Study for IgG Samples Spiked with Different Amount of BSA by MMS.

Libo Wang, RedShiftBio & Brent Kendrick, Elion Labs


Thermal Denaturation Analysis of Bovine Serum Albumin by Microfluidic Modulation Spectroscopy.

Lucy Liu, Pfizer


Repeatability , Concentration Linearity and High Order Structure Analysis of an IgG1 Sample by Microfluidic Modulation Spectroscopy (MMS).

Libo Wang, RedShiftBio & Lucy Liu, Pfizer


Enhanced Protein Structural Characterization using MMS.

Eugene Ma, RedShiftBio


Early Events in Amyloid Formation by Lysozyme Detected by Microfluidic Modulation Spectroscopy.

Quichen Zheng, Clark University & Libo Wang, RedShiftBio

Presentations & webinars

Exploring Novel Vaccine Characterization Methodologies Webinar Cover Image

Merck and Fina Biosolutions On Demand Webinar - Watch Now

Understand why protein secondary structure characterization in vaccine development is important

Shedding light on conformational changes during amyloidgenesis

The Department of Bioengineering University of Washington On Demand Webinar - Watch Now

How Microfluidic Modulation Spectroscopy (the AQS3pro) allows users to ‘see change’ in the secondary structure of proteins across a wide concentration range from 0.1 to over 200 mg/ml, and in the presence of excipients.


Amgen On Demand Webinar - Watch Now

An Automated, Higher Performance Infrared (IR) Technology For Structural Analysis of Protein Biopharmaceuticals


KBI Biopharma on Demand Webinar - Watch Now

Comparison between Microfluidic Modulation Spectroscopy and FTIR and CD (Circular Dichroism)


Watch Eugenes PEGS Presentation

Eugene Ma Unveils RedShiftBio's AQS3pro Protein Characterization Instrument

Workflows For Biotherapeutic Higher Order Structure Characterization Webinar Cover Image

Acceleron Pharma and University of Delaware On Demand Webinar - Watch Now

This webinar will present workflows for biotherapeutic characterization, using Microfluidic Modulation Spectroscopy.

NEW Pressure BioSciences image for learn more page

Pressure BioSciences On Demand Webinar - Watch Now

How Microfluidic Modulation Spectroscopy (MMS) with pressure-assisted protein refolding and pressure perturbation can be used to study protein stability in biopharmaceutical formulation development.


Janssen On Demand Webinar - Watch Now

How Microfluidic Modulation Spectroscopy (MMS) can be used to monitor, in real time, conformational changes in a monoclonal antibody


ImmunoGen, Inc and Celldex Therapeutics On Demand Webinar - Watch Now

How Microfluidic Modulation Spectroscopy (MMS) can be used to understand the structures of therapeutic antibodies and antibody drug conjugates


Volume 104, Number 11, November 2015, American Pharmacists Association

the Journal of Pharmaceutical Sciences published a paper authored by a team at Pfizer featuring the AQS3™pro.

Analytical Techniques in the Biopharmaceutical Industry - Microfluidic Modulation Spectroscopy

The Analytical Scientist publishes "In My View" By Jeff Zonderman of RedShiftBio

Shaping IR Spectroscopy into a Powerful Tool for Biopharma Characterizations

Biopharm International publishes a peer reviewed paper co-authored by Higher Order Structure group at Amgen

Native Measurement of a Biotherapeutic without Interference from Excipients Using Microfluidic Modulation Spectroscopy

Spectroscopy NA publishes an article in its IR Supplement from Celldex and RedShiftBio on native measurement of a biotherapeutic without interference from excipients using MMS

Karen Steward: Innovative spectroscopy Is enhancing protein structure determination

Karen Steward from Technology Networks Interviews Julien Bradley on MMS

Feliza Mirasol: BioPharm International Volume 33, Issue 4, pg 28-32

RedShiftBio contributes towards Biosimilars feaure titled Biosimilars Tackle Interchangeability Standards in Biopharm International

To Improve Protein Aggregation Assessments, Combine PCT and MMS

Genetic Engineering News publishes co authored article with RedShiftBio and Pressure BioSciences titled To Improve Protein Aggregation Assessments, Combine PCT and MMS

RedShift BioAnalytics Name New CEO Article

Instrument Business Outlook interviews RedShiftBio CEO Julien Bradley on his new appointment

Determining Spectroscopic Quantitation Limits for Misfolded Structures

A team led by Brent Kendrick at KBI Biopharma, compare and assess FTIR and Circular Dichroism with Microfluidic Modulation Spectroscopy (RedShiftBio) for their ability to detect the presence and quantify the amount of the misfolded structure. in this Journal of Pharmaceutical Sciences paper

Pharmaceutical Technology - Overcoming CMC Challenges

Pharmaceutical Technology North America interviews thought leaders (including Jeff Zonderman) for a feature on accepting the challenge of protein characterization

Biopharm int

Biopharm International interviews scientists with experience of Microfluidic Modulation Spectroscopy for a round-table on how complex protein studies demand dynamic techniques. Visit page 18 to see what Immunogen, Janssen, Elion Labs and the University of Delaware have to say.

Applying Microfluidic Modulation Spectroscopy in Vaccine Formulation

American Pharmaceutical Review Publishes Article On MMS Co Authored with Merck

Am Lab

American Laboratory publishes article on The Evolution of Spectroscopy by Brent Kendrick of Elion Labs and Eugene Ma and Libo Wang of RedShiftBio.


American Pharmaceutical Review publishes article on MMS by Karan K. Shah Principal Development Associate Analytical and Pharmaceutical Sciences ImmunoGen, Inc.


Instrument Business Outlook interviews RedShiftBio CCO Jeff Zonderman on the launch of the AQS3pro.

Spec EU

Spec EU Spectroscopy Europe highlights the launch of the AQS3pro.

Spec NA

Spectroscopy North America publishes peer-reviewed paper on MMS from Brent Kendrick of Elion Labs, Eugene Ma and Libo Wang of RedShiftBio.

Matthew McGann

With the requirements of formulation development of biopharmaceuticals becoming more demanding, the evolution of analytical tools that can measure stability over a wide concentration range, in the presence of complex buffer systems is critical. Read this article in Drug Developmnet & Delivery to understand more about the role that MMS plays in formulation development.

Article Summary Image

A team led by researchers at the University of Washington has developed synthetic peptides that target and inhibit the small, toxic protein aggregates that are thought to trigger Alzheimer's disease

Whitepapers, Application & Technical Notes


MMS For Protein Therapeutic Drug Analysis - White Paper

This whitepaper provides an overview of RedShiftBio’s Microfluidic Modulation Spectroscopy technology and the performance that can be achieved in protein characterization. Specifically the white paper presents significant increases in sensitivity and concentration range for determining protein similarity (fingerprinting), quantitation, protein secondary structure, and protein stability and aggregation through thermal and chemical denaturation methods


Microfluidic Modulation Spectroscopy (MMS) Fills an Analytical Gap with a Lower LOQ for Measuring Protein Misfolds and Structural Similarity

Common structural characterization methods such as FTIR and CD have known limitations in reproducibility and sensitivity which adversely increase the lowest level of quantitation (LOQ) achievable when measuring structural impurities and similarity. This application note will highlight the MMS system developed by RedShiftBio, a new protein characterization method which generates reproducible high resolution measurements. Demonstrated here, across a structural impurity range of 0–10%, are lower LOQ values compared to those possible using FTIR and CD.


Thermal Denaturation Analysis of Bovine Serum Albumin over Wide Concentration Range by Microfluidic Modulation Spectroscopy

In this note, MMS was used to study the heat-induced thermal denaturation of BSA. The results show replicate measurements are very reproducible (99% similarity), and that MMS provides accurate secondary structure measurements for protein samples over a wide concentration range
(1 to 100 mg/mL).


Monoclonal Antibody Analysis by Microfluidic Modulation Spectroscopy in a Complex Formulation Buffer (1 to 150 mg/mL)

This note demonstrates that MMS enables quantitative analysis of monoclonal antibodies over a wide concentration range with high reproducibility and accuracy.

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